Tyrosine Hydroxylase Recombinant Rabbit Monoclonal Antibody [SN59-03] (ET1611-12)

UNIPROT #

P07101

PROTEIN NAME

Tyrosine Hydroxylase

SYNONYMS

Dystonia 14 antibody;DYT14 antibody;DYT5b antibody;EC 1.14.16.2 antibody;OTTHUMP00000011225 antibody;OTTHUMP00000011226 antibody;ple antibody;Protein Pale antibody;TH antibody;The antibody;TY3H_HUMAN antibody;TYH antibody;Tyrosine 3 hydroxylase antibody;Tyrosine 3 monooxygenase antibody;Tyrosine 3-hydroxylase antibody;Tyrosine 3-monooxygenase antibody;Tyrosine hydroxylase antibody

SEQUENCE SIMILARITIES

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

TISSUE SPECIFICITY

Mainly expressed in the brain and adrenal glands.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen (O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla. Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs).