Ubiquitin D Recombinant Rabbit Monoclonal Antibody [JJ084-09] (ET1701-9)

UNIPROT #

O15205

PROTEIN NAME

Ubiquitin D

SYNONYMS

Diubiquitin antibody;FAT10 antibody;GABBR1 antibody;UBD 3 antibody;Ubd antibody;UBD_HUMAN antibody;Ubiquitin D antibody;Ubiquitin like protein FAT10 antibody;Ubiquitin-like protein FAT10 antibody

TISSUE SPECIFICITY

Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland.

POST-TRANSLATIONAL MODIFICATION

Can be acetylated.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

FAT10, also designated Ubiquitin D or Diubiquitin, is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin. Each domain contains two cysteines, along with a free C-terminal diglycine motif required for FAT10 conjugate formation. FAT10 is inducible by interferon-g and tumor necrosis factor a (TNF?). The FAT10 protein interacts with MAD2, a component of the spindle checkpoint, and plays a role in antigen presentation, cytokine response, apoptosis and mitosis. It may also regulate cell growth during dendritic cell or B cell activation and development. FAT10 mRNA is expressed mainly in some dendritic cells and lymphoblastoid lines and in other specific cells subsequent to interferon-g induction. The human FAT10 gene, designated UBD, maps to chromosome 6p21.3 and is overexpressed in the tumors of various epithelial cancers.