UCHL5IP Recombinant Rabbit Monoclonal Antibody [JE65-32] (HA721077)

UNIPROT #

Q99871

PROTEIN NAME

UCHL5IP

SYNONYMS

26S proteasome-associated UCH interacting protein 1 antibody;26S proteasome-associated UCH37-interacting protein 1 antibody;Expressed-Xq28STS protein antibody;HAUS augmin-like complex subunit 7 antibody;Haus7 antibody;HAUS7_HUMAN antibody;HSXQ28ORF antibody;UCH37 interacting protein 1 antibody;UCHL5 interacting protein antibody;UCHL5-interacting protein antibody;UCHL5IP antibody;UIP1 antibody;X-linked protein STS1769 antibody

SUBCELLULAR LOCATION

Centrosome, spindle.

FUNCTION

This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake. HAUS7 (HAUS Augmin Like Complex Subunit 7) is a Protein Coding gene. Diseases associated with HAUS7 include Vas Deferens, Congenital Bilateral Aplasia Of. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include thioesterase binding. Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.