UCP1 Rabbit Polyclonal Antibody (HA500118)

UNIPROT #

P25874

PROTEIN NAME

UCP1

SYNONYMS

mitochondrial brown fat uncoupling protein antibody;Mitochondrial brown fat uncoupling protein 1 antibody;SLC25A7 antibody;Solute carrier family 25 member 7 antibody;Thermogenin antibody;UCP 1 antibody;UCP antibody;UCP1 antibody;UCP1_HUMAN antibody;uncoupling protein 1 (mitochondrial, proton carrier) antibody;Uncoupling protein 1 antibody

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.