USP8 Rabbit Polyclonal Antibody (HA500362)

UNIPROT #

P40818

PROTEIN NAME

USP8

SYNONYMS

Deubiquitinating enzyme 8 antibody;FLJ34456 antibody;hUBPy antibody;HumORF8 antibody;KIAA0055 antibody;MGC129718 antibody;SPG59 antibody;Ubiquitin carboxyl-terminal hydrolase 8 antibody;Ubiquitin isopeptidase Y antibody;ubiquitin specific peptidase 8 antibody;Ubiquitin thioesterase 8 antibody;Ubiquitin-specific-processing protease 8 antibody;UBP8_HUMAN antibody;UBPY antibody;Usp8 antibody

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane, Nucleus.

FUNCTION

Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation.