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VEGF Rabbit Polyclonal Antibody (ER30607)

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Catalog# ER30607

Rabbit Polyclonal to VEGF

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Rabbit polyclonal primary

Product Name

VEGF Rabbit Polyclonal Antibody (ER30607)

Immunogen

Synthetic peptide within n-terminal human vegfa.

Host

Rabbit

Positive Control

HeLa cell lysate, SH-SY5Y cell lysate, HUVEC cell lysate, MCF7 cell lysate, U-87 MG cell lysate, K-562 cell lysate, HepG2, HUVEC, human lung carcinoma tissue, Hela.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069553

APPLICATION DILUTION

  • WB

  • 1:5,000

  • IF-Cell

  • 1:200

  • IHC-P

  • 1:200

  • FC

  • 1:100-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 27 kDa

Isotype

IgG

TARGET

UNIPROT #

P15692

PROTEIN NAME

VEGF

SYNONYMS

Folliculostellate cell-derived growth factor antibody;Glioma-derived endothelial cell mitogen antibody;MGC70609 antibody;MVCD1 antibody;Vascular endothelial growth factor A antibody;vascular endothelial growth factor A121 antibody;vascular endothelial growth factor A165 antibody;vascular endothelial growth factor antibody;Vascular permeability factor antibody;VEGF A antibody;Vegf antibody;VEGF-A antibody;VEGF120 antibody;Vegfa antibody;VEGFA_HUMAN antibody;VPF antibody

SEQUENCE SIMILARITIES

Belongs to the PDGF/VEGF growth factor family.

TISSUE SPECIFICITY

Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development.

CITATIONS

  • Du W, Chen W, Wang J, et al

    A dual-nanozyme-loaded black phosphorus multifunctional therapeutic platform for combined photothermal/photodynamic/starvation cancer therapy

  • miR‑3133 inhibits proliferation and angiogenesis by targeting the JUNB/VEGF pathway in human umbilical vein endothelial cells

  • Yin, X., Teng, X., Ma, T., Yang, T., Zhang, J., Huo, M., Liu, W., Yang, Y., Yuan, B., Yu, H., Huang, W., & Wang, Y.

    RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis

  • Wenming Xu

    Deficiency of DICER reduces the invasion ability of trophoblasts and impairs the pro-angiogenic effect of trophoblast-derived microvesicles

  • Chen Tingting,et al

    The Dual Angiogenesis Effects via Nrf2/HO-1 Signaling Pathway of Melatonin Nanocomposite Scaffold on Promoting Diabetic Bone Defect Repair

  • Caiqiao Zhang

    Effect of dietary N-carbamylglutamate on development of ovarian follicles via enhanced angiogenesis in the chicken.

  • Hong Yu

    Growth differentiation factor 11 promotes differentiation of MSCs into endothelial-like cells for angiogenesis

  • Xujun He

    Upregulation of miRNA-301a-3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF-κB signaling

  • Liao Jinfeng,et al

    Photothermal Sensitive Nanocomposite Hydrogel for Infectious Bone Defects

  • Yufei Fu

    SOX5 induces lung adenocarcinoma angiogenesis by inducing the expression of VEGF through STAT3 signaling

  • Li, Q., Luo, H., Dai, F. Q., Wang, R. T., Fan, X. Q., Luo, Y. Y., Deng, M. S., Wang, Y., Long, T., Guo, W., Xu, B., Xu, C. X., & Jin, H.

    SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell Carcinoma by Stimulating MYH9-Mediated GSK3β/β-Catenin Signaling

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