VEGF Receptor 1 Recombinant Rabbit Monoclonal Antibody [SY09-09] (ET1605-11)

UNIPROT #

P17948

PROTEIN NAME

VEGF Receptor 1

SYNONYMS

EC 2.7.10.1 antibody;FLT 1 antibody;FLT antibody;Flt-1 antibody;FLT1 antibody;Fms like tyrosine kinase 1 antibody;Fms related tyrosine kinase 1 antibody;Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody;Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor antibody;Fms-like tyrosine kinase 1 antibody;FRT antibody;Soluble VEGF receptor 1 14 antibody;Soluble VEGFR1 variant 2 antibody;Soluble VEGFR1 variant 21 antibody;Tyrosine protein kinase FRT antibody;Tyrosine protein kinase receptor FLT antibody;Tyrosine-protein kinase FRT antibody;Tyrosine-protein kinase receptor FLT antibody;Vascular endothelial growth factor receptor 1 antibody;Vascular endothelial growth factor vascular permeability factor receptor antibody;Vascular permeability factor receptor 1 antibody;Vascular permeability factor receptor antibody;VEGFR 1 antibody;VEGFR-1 antibody;VEGFR1 antibody;VGFR1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.

TISSUE SPECIFICITY

Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed in placenta. Isoform 3 is expressed in corneal epithelial cells (at protein level). Isoform 3 is expressed in vascular smooth muscle cells (VSMC).

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.; Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation.; Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1, PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL, NCK1 and CRK. Is probably dephosphorylated by PTPRB.

SUBCELLULAR LOCATION

Cell membrane, Endosome, Secreted, Cytoplasm.

FUNCTION

Three cell membrane receptor tyrosine kinases, Flt (also designated VEGF-R1), Flk-1 (also designated VEGF-R2) and Flt-4, putatively involved in the growth of endothelial cells, are characterized by the presence of seven immunoglobulin-like sequences in their extracellular domain. These receptors exhibit high degrees of sequence relatedness to each other as well as lesser degrees of relatedness to the class III receptors including CSF-1/Fms, PDGR, SLFR/Kit and Flt-3/Flk-2. Two members of this receptor class, Flt-1 and Flk-1, have been shown to represent high affinity receptors for vascular endothelial growth factors (VEGFs). On the basis of structural similarity to Flt and Flk-1, it has been speculated that Flt-4 might represent a third receptor for either VEGF or a VEGF-related ligand.