VEGFD Recombinant Rabbit Monoclonal Antibody [JE54-75] (ET7110-81)

UNIPROT #

O43915

PROTEIN NAME

VEGFD

SYNONYMS

c-fos induced growth factor antibody;c-fos induced growth factor (vascular endothelial growth factor D) antibody;c-fos induced growth factor antibody;c-fos-induced growth factor antibody;FIGF antibody;Vascular endothelial growth factor D antibody;Vascular endothelial growth factor D precursor antibody;Vascular endothelial growth factor D precursor antibody;VEGF D antibody;VEGF-D antibody;VEGFD antibody;VEGFD_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the PDGF/VEGF growth factor family.

TISSUE SPECIFICITY

Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.

POST-TRANSLATIONAL MODIFICATION

Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. Diseases associated with VEGFD include Anal Canal Squamous Cell Carcinoma and Kidney Angiomyolipoma. Among its related pathways are ERK Signaling and Ras signaling pathway. An important paralog of this gene is VEGFC.