Vitamin K-dependent protein S Rabbit Polyclonal Antibody (0812-4)

UNIPROT #

P07225

PROTEIN NAME

Vitamin K-dependent protein S

SYNONYMS

Preproprotein S antibody;Propiece of latent protein S antibody;PROS 1 antibody;PROS antibody;PROS_HUMAN antibody;proS1 antibody;Protein S alpha antibody;Protein Sa antibody;PS 21 antibody;PS 22 antibody;PS 23 antibody;PS 24 antibody;PS 25 antibody;PS 26 antibody;PS21 antibody;PS22 antibody;PS23 antibody;PS24 antibody;PS25 antibody;PS26 antibody;PSA antibody;THPH5 antibody;THPH6 antibody;Vitamin K dependent protein S antibody;Vitamin K-dependent plasma protein S antibody;Vitamin K-dependent protein S antibody

TISSUE SPECIFICITY

Plasma.

POST-TRANSLATIONAL MODIFICATION

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

SUBCELLULAR LOCATION

Secretory protein

FUNCTION

Protein S is a vitamin K-dependent plasma glycoprotein synthesized in the endothelium. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b. In the plasma, circulating Protein S becomes inactive upon complexing with C4b-binding protein (C4BP); 60-70% of Protein S circulates in complex with C4BP. Its major function is as a cofactor to facilitate the action of activated protein C (APC) on its substrates, activated factor V (FVa), and activated factor VIII (FVIIIa).