Vitronectin Recombinant Rabbit Monoclonal Antibody [ST49-02] (ET1609-39)

UNIPROT #

P04004

PROTEIN NAME

Vitronectin

SYNONYMS

Complement S Protein antibody;Epibolin antibody;S Protein antibody;S-protein antibody;Serum Spreading Factor antibody;Serum-spreading factor antibody;Somatomedin B antibody;Somatomedin-B antibody;V75 antibody;Vitronectin V10 subunit antibody;Vitronectin V65 subunit antibody;VN antibody;VNT antibody;VTN antibody;VTNC_HUMAN antibody

TISSUE SPECIFICITY

Expressed in the retina pigment epithelium (at protein level). Expressed in plasma (at protein level). Expressed in serum (at protein level).

POST-TRANSLATIONAL MODIFICATION

Sulfated on tyrosine residues.; N- and O-glycosylated.; Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.; It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.; Phosphorylation sites are present in the extracellular medium.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.