VPS35 Recombinant Rabbit Monoclonal Antibody [JB33-82] (ET7107-01)

UNIPROT #

Q96QK1

PROTEIN NAME

VPS35

SYNONYMS

DKFZp434E1211 antibody;DKFZp434P1672 antibody;FLJ10752 antibody;FLJ13588 antibody;FLJ20388 antibody;hVPS35 antibody;Maternal embryonic 3 antibody;Maternal-embryonic 3 antibody;MEM 3 antibody;MEM3 antibody;PARK17 antibody;TCCCTA00141 antibody;Vacuolar protein sorting 35 (yeast) antibody;Vacuolar protein sorting 35 antibody;Vacuolar protein sorting 35 homolog antibody;Vacuolar protein sorting associated protein 35 antibody;Vacuolar protein sorting-associated protein 35 antibody;Vesicle protein sorting 35 antibody;VPS 35 antibody;VPS35 antibody;VPS35_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the VPS35 family.

TISSUE SPECIFICITY

Ubiquitous. Highly expressed in heart, brain, placenta, skeletal muscle, spleen, thymus, testis, ovary, small intestine, kidney and colon.

SUBCELLULAR LOCATION

Cytoplasm. Membrane. Endosome.

FUNCTION

Vacuolar sorting proteins (VPSs) are required for proper trafficking of endocytic and biosynthetic proteins to the vacuole and play an important role in the budding process of cells. VPS35 (vacuolar protein sorting 35), also known as MEM3, is the 796 amino acid human homolog of the S. cerevisiae Vps35 protein. Localized to the cytoplasm and to the peripheral membrane, VPS35 is an essential component of the retromer complex which is involved in retrieval of lysosomal enzyme receptors from endosomes to the trans-Golgi network. VPS35 is expressed ubiquitously with highest expression in heart, placenta, brain, testis, kidney, colon, ovary and spleen. In addition to its crucial role in the retromer complex, VPS35 is part of a subcomplex that is required to regulate transcytosis of the polymeric immunoglobulin receptor from the basolateral to the apical surface of epithelial cells and hepatocytes.