WASP Recombinant Rabbit Monoclonal Antibody [JE36-82] (HA721659)

UNIPROT #

P42768

PROTEIN NAME

WASP

SYNONYMS

Eczema thrombocytopenia antibody;IMD2 antibody;SCNX antibody;THC antibody;THC1 antibody;Thrombocytopenia 1 (X linked) antibody;U42471 antibody;Was antibody;WASp antibody;WASP_HUMAN antibody;Wiskott Aldrich syndrome (eczema thrombocytopenia) antibody;Wiskott Aldrich syndrome antibody;Wiskott Aldrich syndrome protein antibody;Wiskott-Aldrich syndrome protein antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton, Nucleus.

FUNCTION

The Wiskott–Aldrich Syndrome protein (WASp) is a 502-amino acid protein expressed in cells of the hematopoietic system that in humans is encoded by the WAS gene. In the inactive state, WASp exists in an autoinhibited conformation with sequences near its C-terminus binding to a region near its N-terminus. Its activation is dependent upon CDC42 and PIP2 acting to disrupt this interaction, causing the WASp protein to 'open'. This exposes a domain near the WASp C-terminus that binds to and activates the Arp2/3 complex. Activated Arp2/3 nucleates new F-actin. WASp is the founding member of a gene family which also includes the broadly expressed N-WASP (neuronal Wiskott–Aldrich Syndrome protein), SCAR/WAVE1, WASH, WHAMM, and JMY. WAML (WASP and MIM like), WAWH (WASP without WH1 domain), and WHIMP (WAVE Homology in Membrane Protrusions) have more recently been discovered.