WDR5 Rabbit Polyclonal Antibody (R1512-17)

UNIPROT #

P61964

PROTEIN NAME

WDR5

SYNONYMS

2410008O07Rik antibody;AA408785 antibody;AA960360 antibody;BIG 3 antibody;Big antibody;BIG3 antibody;BMP2 induced 3 kb gene protein antibody;BMP2 induced gene, 3-KB antibody;BMP2-induced 3-kb gene protein antibody;MGC114572 antibody;OTTHUMP00000162494 antibody;SWD 3 antibody;SWD3 antibody;SWD3 Set1c WD40 repeat protein homolog antibody;WD repeat containing protein 5 antibody;WD repeat domain 5 antibody;WD repeat protein 5 antibody;WD repeat-containing protein 5 antibody;WD repeat-containing protein BIG-3 antibody;WDR 5 antibody;Wdr5 antibody;WDR5_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the WD repeat WDR5/wds family.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.