XBP1 Recombinant Rabbit Monoclonal Antibody [JM10-62] (ET1703-23)

UNIPROT #

P17861

PROTEIN NAME

XBP1

SYNONYMS

Tax responsive element binding protein 5 antibody;Tax-responsive element-binding protein 5 antibody;TREB5 antibody;X box binding protein 1 antibody;X box binding protein 2 antibody;X-box-binding protein 1 antibody;XBP 1 antibody;XBP-1 antibody;XBP1 antibody;XBP1_HUMAN antibody;XBP2 antibody

SEQUENCE SIMILARITIES

Belongs to the bZIP family.

TISSUE SPECIFICITY

Expressed in plasma cells in rheumatoid synovium. Over-expressed in primary breast cancer and metastatic breast cancer cells. Isoform 1 and isoform 2 are expressed at higher level in proliferating as compared to confluent quiescent endothelial cells.

POST-TRANSLATIONAL MODIFICATION

[Isoform 2]: Acetylated by EP300; acetylation positively regulates the transcriptional activity of XBP1 isoform 2. Isoform 2 is deacetylated by SIRT1; deacetylation negatively regulates the transcriptional activity of XBP1 isoform 2.; [Isoform 1]: Ubiquitinated, leading to proteasome-mediated degradation in response to ER stress.; X-box-binding protein 1, cytoplasmic form and luminal form are produced by intramembrane proteolytic cleavage of ER membrane-anchored isoform 1 triggered by HM13/SPP in a DERL1-RNF139-dependent and VCP/p97-independent manner. X-box-binding protein 1, luminal form is ubiquitinated leading to proteasomal degradation.

SUBCELLULAR LOCATION

Nucleus, Chromosome.

FUNCTION

X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response. It was first identified by its ability to bind to the Xbox, a conserved transcriptional element in the promoter of the human leukocyte antigen (HLA) DR alpha. Abnormalities in XBP1 lead to a heightened ER stress and subsequently causes a heightened susceptibility for inflammatory processes that may contribute to Alzheimer's disease. In the colon, XBP1 anomalies have been linked to Crohn's disease.