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xCT/SLC7A11 Recombinant Rabbit Monoclonal Antibody [JE31-93] (HA721868)

Price: Regular price $385.00

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Catalog# HA721868

Rabbit Monoclonal to xCT/SLC7A11

Tested for

  • WB

  • IP

Reacts with

  • Human

  • Mouse

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

xCT/SLC7A11 Recombinant Rabbit Monoclonal Antibody [JE31-93] (HA721868)

Immunogen

Synthetic peptide within human xct aa 1-50 / 501.

Host

Rabbit

Positive Control

HepG2 cell lysate, HeLa cell lysate, 293T cell lysate, Mouse liver tissue lysate, Mouse brain tissue lysate, Rat brain tissue lysate, Rat liver tissue lysate, PC-12 cell lysates.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JE31-93

RRID

AB_3096828

APPLICATION DILUTION

  • WB

  • 1:1,000

  • IP

  • 1-2μg/sample

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 55 kDa

Isotype

IgG

TARGET

UNIPROT #

Q9UPY5

PROTEIN NAME

xCT/SLC7A11

SYNONYMS

Amino acid transport system xc xCT antibody antibody;Amino acid transport system xc- antibody;Calcium channel blocker resistance protein CCBR1 antibody;Calcium channel blocker resistance protein CCBR1 antibody antibody;CCBR1 antibody;Cysteine/glutamate transporter antibody antibody;Cystine/glutamate transporter antibody;OTTHUMP00000164578 antibody;SLC7A11 antibody;Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 antibody;solute carrier family 7 antibody;Solute carrier family 7 member 11 antibody;Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antibody;SYSTEM Xc(-) TRANSPORTER-RELATED PROTEIN antibody;xCT antibody;XCT_HUMAN antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

CITATIONS

  • Boosting ferroptosis and microtubule inhibition for antitumor therapy via a carrier-free supermolecule nanoreactor

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