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YARS2 Rabbit Polyclonal Antibody (ER1902-50)

Price: Regular price $315.00

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Catalog# ER1902-50

Rabbit Polyclonal to YARS2

Tested for

  • IF-Tissue

  • IHC-P

Reacts with

  • Zebrafish

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

YARS2 Rabbit Polyclonal Antibody (ER1902-50)

Immunogen

Recombinant protein within zebrafish yars2 aa 251-474 / 474.

Host

Rabbit

Positive Control

Zebrafish.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3069434

APPLICATION DILUTION

  • IF-Tissue:1:50-1:200

  • IHC-P:1:50-1:200

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 53 kDa

Isotype

IgG

TARGET

UNIPROT #

F1Q4R5

PROTEIN NAME

YARS2

SYNONYMS

CGI 04 antibody;FLJ13995 antibody;mitochondrial antibody;MLASA2 antibody;mt TyrRS antibody;SYYM_HUMAN antibody;Tyrosine tRNA ligase 2 mitochondrial antibody;Tyrosine tRNA ligase antibody;Tyrosine tRNA ligase mitochondrial antibody;Tyrosine--tRNA ligase antibody;Tyrosyl tRNA synthetase 2 mitochondrial antibody;Tyrosyl tRNA synthetase mitochondrial precursor antibody;Tyrosyl-tRNA synthetase antibody;TyrRS antibody;YARS 2 antibody;YARS2 antibody

SEQUENCE SIMILARITIES

Belongs to the class-I aminoacyl-tRNA synthetase family.

SUBCELLULAR LOCATION

Cytosol. Mitochondrion.

FUNCTION

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS2 are the cause of myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2) [MIM:613561]. MLASA2 is a rare oxidative phosphorylation disorder specific to skeletal muscle and bone marrow. Affected individuals manifest sideroblastic anemia, progressive lethargy, muscle weakness, and exercise intolerance associated with persistent lactic acidemia.

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