Yes1 Recombinant Rabbit Monoclonal Antibody [JE37-26] (HA721563)

UNIPROT #

P07947

PROTEIN NAME

Yes1

SYNONYMS

c Yes antibody;Cellular Yes 1 protein antibody;Cellular Yes1 protein antibody;HsT441 antibody;P61 YES antibody;p61-Yes antibody;Proto oncogene tyrosine protein kinase YES antibody;Proto-oncogene c-Yes antibody;Tyrosine-protein kinase Yes antibody;v yes 1 Yamaguchi sarcoma viral oncogene homolog 1 antibody;Viral oncogene yes 1 homolog 1 antibody;Viral oncogene yes1 homolog 1 antibody;Yamaguchi sarcoma oncogene antibody;Yes 1 antibody;Yes antibody;YES proto oncogene 1, Src family tyrosine kinase antibody;YES_HUMAN antibody;YES1 antibody;YES1 proto oncogene, Src family tyrosine kinase antibody

SUBCELLULAR LOCATION

Cytoplasm > cytosol.

FUNCTION

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity.