Zic1 Recombinant Rabbit Monoclonal Antibody [JA31-60] (ET1704-96)

UNIPROT #

Q15915

PROTEIN NAME

Zic1

SYNONYMS

Odd paired homolog Drosophila antibody;Zic 1 antibody;ZIC antibody;Zic family member 1 (odd-paired Drosophila homolog) antibody;Zic family member 1 antibody;Zic protein member 1 antibody;zic1 antibody;ZIC1_HUMAN antibody;Zinc finger protein 201 antibody;Zinc finger protein of the cerebellum 1 antibody;Zinc finger protein ZIC 1 antibody;Zinc finger protein ZIC1 antibody;ZNF 201 antibody;ZNF201 antibody

SEQUENCE SIMILARITIES

Belongs to the GLI C2H2-type zinc-finger protein family.

TISSUE SPECIFICITY

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

ZIC1 is a member of the Zinc finger of the cerebellum (ZIC) protein family. ZIC1 is classified as a ZIC protein due to conservation of the five C2H2 zinc fingers, which enables the protein to interact with DNA and proteins. ZIC1 is found in close genomic configuration in another member of this protein family, ZIC4. Correct function of these proteins is critical for early development, and as such mutations of the genes encoding these proteins is known to result in various congenital defects. For example, if function of both ZIC1 and ZIC4 is lost (which can occur via an interstitial deletion due to their adjacent location) then this may result in the Dandy-Walker malformation.