CCDC47 Rabbit Polyclonal Antibody

Function

Coiled-coil domain 47 (CCDC47) is a gene located on human chromosome 17, specifically locus 17q23.3 which encodes for the protein CCDC47. The gene has several aliases including GK001 and MSTP041. The protein itself contains coiled-coil domains, the SEEEED superfamily, a domain of unknown function (DUF1682) and a transmembrane domain. The function of the protein is unknown, but it has been proposed that CCDC47 is involved in calcium ion homeostasis and the endoplasmic reticulum overload response. Microarray tissue expression patterns from GEO were analyzed and showed that CCDC47 appears to be an ubiquitously expressed at moderate levels in many different human tissues. Although the protein is ubiquitously expressed, the highest levels of expression are seen in neuronal tissues such as the superior cervical ganglion, brain amygdala and ciliary ganglion. Elevated expression is also seen in the thyroid and CD34+ cells.

Background References

1. Wu WS et al. Human CCDC47 sandwich immunoassay development with electrochemiluminescence technology. J Immunol Methods. 2018 Jan

2. Thapa K et al. Dysregulation of the calcium handling protein, CCDC47, is associated with diabetic cardiomyopathy. Cell Biosci. 2018 Aug

Subcellular Location

Endoplasmic reticulum membrane, Rough endoplasmic reticulum membrane.

UNIPROT

SwissProt: Q96A33 Human

SwissProt: Q9D024 Mouse

SwissProt: Q5U2X6 Rat

Synonyms

CCD47_HUMAN antibody

CCDC 47 antibody

CCDC47 antibody

Coiled coil domain containing 47 antibody

Coiled coil domain containing protein 47 antibody

Coiled-coil domain-containing protein 47 antibody

GK001 antibody

MSTP041 antibody