TSHR Rabbit Polyclonal Antibody
Catalog# ER1918-20
TSHR Rabbit Polyclonal Antibody
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ELISA
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Human
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Mouse
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Rat
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unconjugated
Overview
Product Name
TSHR Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
KLH conjugated synthetic peptide derived from human TSHR 501-600/764
Species Reactivity
Human, Mouse, Rat
Validated Applications
ELISA
Molecular Weight
86 KDa
Positive Control
Expressed in the thyroid.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage Buffer
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
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ELISA
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1:5000-10000
Target
Function
Various hormones are secreted from the anterior pituitary during development and growth, including thyroid-stimulating hormone (TSH, also known as thyrotropin), follicle-stimulating hormone (FSH) and leutinizing hormone (LH). TSH, FSH, and LH are heterodimers formed from a common alpha chain and a unique beta chain. TSH is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
Background References
暂无
Subcellular Location
Cell membrane; Multi-pass membrane protein.
UNIPROT
Synonyms
CHNG1 antibody
hTSHR I antibody
hTSHRI antibody
LGR 3 antibody
LGR3 antibody
MGC75129 antibody
Seven transmembrane helix receptor antibody
Thyroid adenoma hyperfunctioning antibody
Thyroid carcinoma with thyrotoxicosis antibody
Thyroid stimulating hormone receptor antibody
ExpandImages
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Sample:
Thyroid gland (Mouse) Lysate at 40 ug
Primary: Anti-TSHR (ER1918-20) at 1/300 dilution
Secondary: Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 86 kD
Observed band size: 86 kD -
Sample:
Thyroid gland (Rat) Lysate at 40 ug
Primary: Anti-TSHR (ER1918-20) at 1/300 dilution
Secondary: Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 86 kD
Observed band size: 86 kD
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"