Liver Arginase Recombinant Rabbit Monoclonal Antibody
Catalog# IRS081RB
Liver Arginase Recombinant Rabbit Monoclonal Antibody
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mIHC
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Human
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unconjugated
Overview
Product Name
Liver Arginase Recombinant Rabbit Monoclonal Antibody
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
A synthesized peptide derived from human Arginase 1
Species Reactivity
Human
Validated Applications
mIHC
Molecular Weight
Predicted band size: 35 kDa
Positive Control
Human tonsil tissue.
Conjugation
unconjugated
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Affinity-chromatography
Application Dilution
-
mIHC
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1:100
Target
Function
Arginase I (also designated liver-type arginase), which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea. The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence.
Background References
1. Tengbom J. et. al. Arginase 1 is upregulated at admission in patients with ST-elevation myocardial infarction. J Intern Med. 2021 Nov
2. Kim SH. et. al. Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma. J Vet Sci. 2021 Sep
Subcellular Location
Cytoplasm, Cytoplasmic granule.
UNIPROT
Synonyms
A I antibody
Al antibody
ARG 1 antibody
arg1 antibody
ARGI1_HUMAN antibody
Arginase 1 antibody
Arginase liver antibody
Arginase type I antibody
Arginase, liver antibody
Arginase-1 antibody
ExpandImages
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mIHC analysis of human tonsil tissue (Formalin/PFA-fixed paraffin-embedded sections) with Rabbit anti-Liver Arginase antibody (IRS081RB) at 1/100 dilution. The immunostaining was performed with the IRISKitCmTSA Kit (900808). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 30 mins at 95℃. DAPI (blue) was used as a nuclear counter stain. Image acquisition was performed with Olympus VS200 Slide Scanner.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"