Fibronectin Recombinant Monoclonal Antibody

Function

Fibronectin is an extracellular matrix glycoprotein present on most cell surfaces, in extracellular fluids and in plasma. A high molecular weight heterodimeric protein, it was originally discovered as a protein missing from the surfaces of virus-transformed cells, and it has been shown to be involved in various functions including cell adhesion, cell motility and wound healing. Alternative splicing and glycosylation give rise to several different forms of Fibronectin, some of which exhibit restricted tissue distribution or association with malignancies. It has been shown that Myofibroblast phenotype formation correlates with the occurrence of glycosylated Fibronectin and Fibronectin splice variants in Dupuytren's disease.

Background References

1. Patten J et al. Fibronectin in development and wound healing. Adv Drug Deliv Rev. 2021 Mar

2. Dalton CJ et al. Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling. Cells. 2021 Sep

Subcellular Location

Secreted, extracellular space, extracellular matrix.

UNIPROT

SwissProt: P11276 Mouse

Synonyms