SENP2 Recombinant Rabbit Monoclonal Antibody [JE52-69] (ET7110-33)

UNIPROT #

Q9HC62

PROTEIN NAME

SENP2

SYNONYMS

Axam2 antibody;DKFZp762A2316 antibody;KIAA1331 antibody;Senp2 antibody;SENP2_HUMAN antibody;Sentrin specific protease 2 antibody;Sentrin-specific protease 2 antibody;Sentrin/SUMO specific protease SENP2 antibody;Sentrin/SUMO-specific protease SENP2 antibody;SMT3 specific isopeptidase 2 antibody;SMT3-specific isopeptidase 2 antibody;Smt3ip2 antibody;SUMO1/sentrin/SMT3 specific peptidase 2 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C48 family.

POST-TRANSLATIONAL MODIFICATION

Polyubiquitinated; which leads to proteasomal degradation.

SUBCELLULAR LOCATION

Cytoplasm, Membrane, Nuclear pore complex, Nucleus.

FUNCTION

Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB.