Phospho-DRP1 (S616) Recombinant Rabbit Monoclonal Antibody [PSH06-77] (HA722760)

UNIPROT #

O00429

PROTEIN NAME

Phospho-DRP1 (S616)

SYNONYMS

DLP1 antibody;dnm1l antibody;DNM1L_HUMAN antibody;Dnm1p/Vps1p-like protein antibody;dnml1 antibody;DRP1 antibody;DVLP antibody;Dymple antibody;Dynamin 1 like antibody;Dynamin family member proline-rich carboxyl-terminal domain less antibody;Dynamin like protein antibody;Dynamin related protein 1 antibody;Dynamin-1-like protein antibody;Dynamin-like protein 4 antibody;Dynamin-like protein antibody;Dynamin-like protein IV antibody;Dynamin-related protein 1 antibody;DYNIV 11 antibody;EMPF antibody;EMPF1 antibody;FLJ41912 antibody;HdynIV antibody;VPS1 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Golgi apparatus, Endomembrane system, Mitochondrion outer membrane, Peroxisome, Membrane, clathrin-coated pit, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.

FUNCTION

Dynamin-1-like protein is a GTPase that regulates mitochondrial fission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related protein 1 (Drp1), is encoded by the DNM1L gene and is part of the dynamin superfamily (DSP) family of proteins. Mitochondria routinely undergo fission and fusion events that maintain a dynamic reticular network. Drp1 is a fundamental component of mitochondrial fission. Indeed, Drp1 deficient neurons have large, strongly interconnected mitochondria due to dysfunctional fission machinery. Fission helps facilitate mitophagy, which is the breakdown and recycling of damaged mitochondria. Dysfunction in the DRP activity may result in mutated DNA or malfunctioning proteins diffusing throughout the mitochondrial system. In addition, fission results in fragmented mitochondria more capable of producing of reactive oxygen species, which can disrupt normal biochemical processes inside of cells. ROS can be formed from incomplete transfer of electrons through the electron transport chain. Furthermore, fission influences calcium flux within the cell, linking Drp1 to apoptosis and cancer.