ASK1 Recombinant Rabbit Monoclonal Antibody [SU36-06] (ET1608-54)

UNIPROT #

Q99683

PROTEIN NAME

ASK1

SYNONYMS

Apoptosis signal regulating kinase 1 antibody;Apoptosis signal-regulating kinase 1 antibody;ASK 1 antibody;ASK-1 antibody;ASK1 antibody;M3K5 antibody;M3K5_HUMAN antibody;MAP/ERK kinase kinase 5 antibody;MAP3K5 antibody;MAPK/ERK kinase kinase 5 antibody;MAPKKK5 antibody;MEK kinase 5 antibody;MEKK 5 antibody;MEKK5 antibody;Mitogen activated protein kinase kinase kinase 5 antibody;Mitogen-activated protein kinase kinase kinase 5 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

TISSUE SPECIFICITY

Abundantly expressed in heart and pancreas.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated at Thr-838 through autophosphorylation and by MAP3K6/ASK2 which leads to activation. Thr-838 is dephosphorylated by PPP5C. Ser-83 and Ser-1033 are inactivating phosphorylation sites, the former of which is phosphorylated by AKT1 and AKT2. Phosphorylated at Ser-966 which induces association of MAP3K5/ASK1 with the 14-3-3 family proteins and suppresses MAP3K5/ASK1 activity. Calcineurin (CN) dephosphorylates this site. Also dephosphorylated and activated by PGAM5.; Ubiquitinated. Tumor necrosis factor (TNF) induces TNFR2-dependent ubiquitination leading to proteasomal degradation.

SUBCELLULAR LOCATION

Endoplasmic reticulum, Cytoplasm.

FUNCTION

Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. ASK1 has been found to be involved in cancer, diabetes, rheumatoid arthritis, cardiovascular and neurodegenerative diseases.