Caspase-2 Recombinant Rabbit Monoclonal Antibody [SR44-01] (ET1602-30)

UNIPROT #

P42575

PROTEIN NAME

Caspase-2

SYNONYMS

Caspase2;CASP 2 antibody;CASP-2 antibody;Casp2 antibody;CASP2_HUMAN antibody;Caspase 2 antibody;Caspase 2 apoptosis related cysteine peptidase antibody;Caspase-2 subunit p12 antibody;Caspase2 antibody;ICH 1 antibody;ICH 1 protease antibody;ICH 1L antibody;ICH1 antibody;ICH1 protease antibody;ICH1L antibody;NEDD-2 antibody;NEDD2 antibody;Neural precursor cell expressed developmentally down-regulated protein 2 antibody;PPP1R57 antibody;Protease ICH-1 antibody;Protein phosphatase 1 regulatory subunit 57 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C14A family.

TISSUE SPECIFICITY

Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.

POST-TRANSLATIONAL MODIFICATION

The mature protease can process its own propeptide, but not that of other caspases.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Membrane.

FUNCTION

Caspase-2 (Nedd2, ICH-1) is an aspartate-specific cysteine protease that is activated in response to various apoptotic stimuli. Caspase-2 is unique among the caspases in that it has features of both upstream caspases (long prodomain) and downstream caspases (DEXD substrate specificity). Caspase-2 is highly expressed in the brain during development, and is expressed at low levels in adult tissue. Specifically, caspase-2 localizes to the mitochondria, the Golgi, the cytoplasm, and the nucleus. Caspase-2 exists as two isoforms, caspase-2L and caspase-2S, which are produced by alternative splicing and differ in their N and C-termini. Caspase-2L acts as a positive regulator of apoptosis, whereas caspase-2S functions as a negative regulator of apoptosis. Following apoptotic stimuli, the caspase-2L precursor undergoes cleavage at Asp-153 to produce a fragment (p30). The p30 fragment undergoes further cleavage to generate a fragment containing amino acids 153-308 (p18) and a fragment containing amino acids 317-435 (p13 or p14). As apoptosis progresses, the p13 (p14) fragment can undergo further processing to yield a fragment containing amino acids 331-435 (p12).