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CD8 alpha Recombinant Rabbit Monoclonal Antibody [SI18-01] (ET1606-31)

Price: Regular price $385.00

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Catalog# ET1606-31

Rabbit Monoclonal to CD8 alpha

Tested for

  • WB

  • IF-Cell

  • IF-Tissue

  • IHC-P

  • FC

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
This product has been cited in peer reviewed publications, see list HERE

Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

CD8 alpha Recombinant Rabbit Monoclonal Antibody [SI18-01] (ET1606-31)

Immunogen

Synthetic peptide within human cd8 alpha aa 186-235 / 235.

Host

Rabbit

Positive Control

THP-1 cell lysate, Jurkat cell lysate, PC-3M cell lysate, Hela, CRC, human spleen tissue, human lymph node tissue, human appendix tissue, Jurkat.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SI18-01

RRID

AB_3069732

APPLICATION DILUTION

  • WB

  • 1:2,000

  • IF-Cell

  • 1:50-1:200

  • IF-Tissue

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1:500-1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 26 kDa

Isotype

IgG

TARGET

UNIPROT #

P01732

PROTEIN NAME

CD8 alpha

SYNONYMS

alpha polypeptide (p32) antibody;CD8 antibody;CD8 antigen alpha polypeptide antibody;CD8 antigen alpha polypeptide (p32) antibody;CD8a antibody;CD8A antigen antibody;CD8A molecule antibody;CD8A_HUMAN antibody;Leu2 antibody;Leu2 T lymphocyte antigen antibody;Ly3 antibody;LYT3 antibody;MAL antibody;OKT8 T cell antigen antibody;OTTHUMP00000160760 antibody;OTTHUMP00000160764 antibody;OTTHUMP00000203528 antibody;OTTHUMP00000203721 antibody;p32 antibody;T cell antigen Leu2 antibody;T cell co receptor antibody;T-cell surface glycoprotein CD8 alpha chain antibody;T-lymphocyte differentiation antigen T8/Leu-2 antibody;T8 T cell antigen antibody;T8/Leu-2 T-lymphocyte differentiation antigen antibody

TISSUE SPECIFICITY

CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.

POST-TRANSLATIONAL MODIFICATION

Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts.; O-glycosylated.; Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

The T cell receptor (TCR) is a heterodimer composed of either α and β or γ and δ chains. CD3 chains and the CD4 or CD8 (CD8-α and CD8-β) co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T cytotoxic cells that can be distinguished by their expression of CD4 and CD8 proteins; T helper cells express CD4 proteins and T cytotoxic cells display CD8 proteins. CD8s are cell surface glycoproteins that exist as two chain complex (αα or αβ) receptors that bind class I MHC molecules presented by the antigen-presenting cell (APC). A primary function of CD8 proteins is to facilitate antigen recognition by the TCR and to strengthen the avidity of the TCR-antigen interactions. An additional role for CD8-expressing T cells may be to maintain low levels of HIV expression.

CITATIONS

  • Shen, D. D., Pang, J. R., Bi, Y. P., Zhao, L. F., Li, Y. R., Zhao, L. J., Gao, Y., Wang, B., Wang, N., Wei, L., Guo, H., Liu, H. M., & Zheng, Y. C.

    LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer

  • Construction of a hypoxia-immune-related prognostic panel based on integrated single-cell and bulk RNA sequencing analyses in gastric cancer

  • Shoubing Zhou,et al

    Synergistic approach to combating triple-negative breast cancer: ddr1-targeted antibody-drug conjugate combined with pembrolizumab

  • Chimeric antigen receptor T cells targeting cell surface GRP78 efficiently kill glioblastoma and cancer stem cells

  • Juan Tang;Zhi-Nan Chen

    Programmed Death Ligand 1 Indicates Pre-Existing Adaptive Immune Response by Tumor-Infiltrating CD8+ T Cells in Non-Small Cell Lung Cancer

  • Optimized CAR-T therapy based on spatiotemporal changes and chemotactic mechanisms of MDSCs induced by hypofractionated radiotherapy

  • Hu, W., Chen, J., Qi, L., Ge, W., Zheng, S., & Yang, Y.

    Hypermutated tumours across 11 cancer types show three distinct immune subtypes

  • Pyroptosis predicts immunotherapy outcomes across multiple cancer types

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