Cdk5 Recombinant Rabbit Monoclonal Antibody [SR39-01] (ET1602-17)

UNIPROT #

Q00535

PROTEIN NAME

Cdk5

SYNONYMS

Cdk 5 antibody;Cdk5 antibody;CDK5_HUMAN antibody;Cell division protein kinase 5 antibody;Crk6 antibody;Cyclin dependent kinase 5 antibody;Cyclin-dependent kinase 5 antibody;Protein kinase CDK5 splicing antibody;PSSALRE antibody;Serine threonine protein kinase PSSALRE antibody;Serine/threonine-protein kinase PSSALRE antibody;Tau protein kinase II catalytic subunit antibody;TPKII catalytic subunit antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

TISSUE SPECIFICITY

Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Tyr-15 by ABL1 and FYN, and on Ser-159 by casein kinase 1 promotes kinase activity. By contrast, phosphorylation at Thr-14 inhibits activity.; Phosphorylation at Ser-159 is essential for maximal catalytic activity.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Cell membrane, Perikaryon, Cell junction

FUNCTION

Cyclin dependent kinase 5 is a protein, and more specifically an enzyme, that is encoded by the Cdk5 gene. It was discovered 15 years ago and it is saliently expressed in post-mitotic central nervous system neurons (CNS). The molecule belongs to the cyclin-dependent kinase family. Kinases are enzymes that catalyze reactions of phosphorylation, a process that allows the substrate to gain a phosphate group donated by an organic compound known as ATP. Phosphorylations are of vital importance during glycolysis, therefore, making kinases an essential part of the cell due to their role in the metabolism, cell signaling and many other processes.