DNAJC15 Recombinant Rabbit Monoclonal Antibody [SY26-04] (ET1607-52)

UNIPROT #

Q9Y5T4

PROTEIN NAME

DNAJC15

SYNONYMS

Cell growth inhibiting gene 22 protein antibody;Cell growth-inhibiting gene 22 protein antibody;DJC15_HUMAN antibody;DnaJ (Hsp40) homolog subfamily C member 15 antibody;DNAJ domain containing antibody;DnaJ homolog subfamily C member 15 antibody;DNAJC15 antibody;DNAJD1 antibody;GIG22 antibody;HSD18 antibody;MCJ antibody;Methylation controlled J protein antibody;Methylation-controlled J protein antibody

TISSUE SPECIFICITY

Expressed at highest levels in heart, followed by liver and kidney.

SUBCELLULAR LOCATION

Mitochondrion inner membrane.

FUNCTION

The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of a J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. MCJ (methylation-controlled J protein), also known as HSD18, DNAJD1 or DNAJC15, is a 150 amino acid ubiquitously expressed single-pass membrane protein containing one J domain. Localizing to the golgi apparatus and only present in vertebrates, MCJ may be associated with increased chemotherapeutic resistance in ovarian cancer by inducing expression of the Mdr drug transporter and preventing intracellular drug accumulation.