Filamin A Recombinant Rabbit Monoclonal Antibody [SA30-08] (ET1601-3)

UNIPROT #

P21333

PROTEIN NAME

Filamin A

SYNONYMS

ABP 280 antibody;ABP-280 antibody;Actin-binding protein 280 antibody;Alpha filamin antibody;Alpha-filamin antibody;APBX antibody;CSBS antibody;CVD1 antibody;Endothelial actin binding protein antibody;Endothelial actin-binding protein antibody;Filamin 1 antibody;Filamin A alpha antibody;Filamin A antibody;Filamin-1 antibody;Filamin-A antibody;FLN antibody;FLN-A antibody;FLN1 antibody;FLNA antibody;FLNA_HUMAN antibody;FMD antibody;MNS antibody;NHBP antibody;Non muscle filamin antibody;Non-muscle filamin antibody;OPD antibody;OPD1 antibody;OPD2 antibody;XLVD antibody;XMVD antibody

SEQUENCE SIMILARITIES

Belongs to the filamin family.

TISSUE SPECIFICITY

Ubiquitous.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-2152 is negatively regulated by the autoinhibited conformation of filamin repeats 19-21. Ligand binding induces a conformational switch triggering phosphorylation at Ser-2152 by PKA.; Phosphorylation extent changes in response to cell activation.; Polyubiquitination in the CH1 domain by a SCF-like complex containing ASB2 leads to proteasomal degradation. Prior dissociation from actin may be required to expose the target lysines. Ubiquitinated in endothelial cells by RNF213 downstream of the non-canonical Wnt signaling pathway, leading to its degradation by the proteasome.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Actin-binding protein, or filamin, is a 280-kD protein that crosslinks actin filaments into orthogonal networks in cortical cytoplasm and participates in the anchoring of membrane proteins for the actin cytoskeleton. Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the FLNA gene, is a widely expressed filamin that regulates the reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and secondary messengers. At least 31 disease-causing mutations in this gene have been discovered.