LGR5/GPR49 Recombinant Rabbit Monoclonal Antibody [SU32-04] (ET1608-18)

UNIPROT #

O75473

PROTEIN NAME

LGR5/GPR49

SYNONYMS

FEX antibody;G protein coupled receptor 49 antibody;G protein coupled receptor 67 antibody;g protein-coupled receptor fex antibody;G-protein coupled receptor 49 antibody;G-protein coupled receptor 67 antibody;G-protein coupled receptor HG38 antibody;GPR 49 antibody;GPR 67 antibody;GPR49 antibody;GPR67 antibody;GRP 49 antibody;GRP49 antibody;HG 38 antibody;HG38 antibody;Leucine rich repeat containing G protein coupled receptor 5 antibody;Leucine-rich repeat-containing G-protein coupled receptor 5 antibody;LGR 5 antibody;LGR5 antibody;LGR5_HUMAN antibody;MGC117008 antibody;Orphan G protein coupled receptor HG38 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.

SUBCELLULAR LOCATION

Cell membrane, Golgi apparatus, Membrane.

FUNCTION

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) also known as G-protein coupled receptor 49 (GPR49) or G-protein coupled receptor 67 (GPR67) is a protein that in humans is encoded by the LGR5 gene. It is a member of GPCR class A receptor proteins. R-spondin proteins are the biological ligands of LGR5. LGR5 is expressed across a diverse range of tissue such as in the muscle, placenta, spinal cord and brain and particularly as a biomarker of adult stem cells in certain tissues. LGR5 is a member of the Wnt signaling pathway. Although its ligand remains elusive, it has been shown that costimulation with R-spondin 1 and Wnt-3a induce increased internalization of LGR5. LGR5 also cointernalizes with LRP6 and FZD5 via a clathrin-dependent pathway to form a ternary complex upon Wnt ligand binding. Moreover, the rapid cointernalization of LRP6 by LGR5 induces faster rates of degradation for the former. LGR5 is crucial during embryogenesis as LGR null studies in mice incurred 100% neonatal mortality accompanied by several craniofacial distortions such as ankyloglossia and gastrointestinal dilation.