MEK1 Recombinant Rabbit Monoclonal Antibody [SZ22-01] (ET1603-20)

UNIPROT #

Q02750

PROTEIN NAME

MEK1

SYNONYMS

Dual specificity mitogen activated protein kinase kinase 1 antibody;Dual specificity mitogen-activated protein kinase kinase 1 antibody;ERK activator kinase 1 antibody;MAP kinase kinase 1 antibody;MAP kinase/Erk kinase 1 antibody;MAP2K1 antibody;MAPK/ERK kinase 1 antibody;MAPKK 1 antibody;MAPKK1 antibody;MEK 1 antibody;Mek1 antibody;MEKK1 antibody;Mitogen activated protein kinase kinase 1 antibody;MKK 1 antibody;MKK1 antibody;MP2K1_HUMAN antibody;PRKMK1 antibody;Protein kinase mitogen activated kinase 1 (MAP kinase kinase 1) antibody;Protein kinase mitogen activated, kinase 1 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.

TISSUE SPECIFICITY

Widely expressed, with extremely low levels in brain.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-218 and Ser-222 by MAP kinase kinase kinases (BRAF or MEKK1) positively regulates kinase activity. Also phosphorylated at Thr-292 by MAPK1/ERK2 and at Ser-298 by PAK. MAPK1/ERK2 phosphorylation of Thr-292 occurs in response to cellular adhesion and leads to inhibition of Ser-298 phosphorylation by PAK. Autophosphorylated at Ser-218 and Ser-222, autophosphosphorylation is promoted by NEK10 following UV irradiation.; Acetylation by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Membrane, Cytoskeleton.

FUNCTION

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.