p75 NGF Receptor Recombinant Rabbit Monoclonal Antibody [SA39-02] (ET1601-22)

UNIPROT #

P08138

PROTEIN NAME

p75 NGF Receptor

SYNONYMS

CD271 antibody;CD271 antigen antibody;Gp80 LNGFR antibody;Gp80-LNGFR antibody;Low affinity nerve growth factor receptor antibody;Low affinity neurotrophin receptor p75NTR antibody;Low-affinity nerve growth factor receptor antibody;Nerve growth factor receptor antibody;Nerve growth factor receptor TNFR superfamily member 16 antibody;NGF receptor antibody;Ngfr antibody;p75 ICD antibody;p75 Neurotrophin receptor antibody;p75 NTR antibody;p75(NTR) antibody;p75NTR antibody;TNFR Superfamily Member 16 antibody;TNFRSF16 antibody;TNR16_HUMAN antibody;Tumor necrosis factor receptor superfamily member 16 antibody

POST-TRANSLATIONAL MODIFICATION

N- and O-glycosylated.; O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.; Phosphorylated on serine residues.

SUBCELLULAR LOCATION

Membrane

FUNCTION

The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. p75NTR is a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4. All neurotrophins bind to p75NTR. This also includes the immature pro-neurotrophin forms. Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. p75NTR is involved in pathways that promote neuronal survival and neuronal death.