Survivin Recombinant Rabbit Monoclonal Antibody [SR44-02] (ET1602-43)

UNIPROT #

O70201

PROTEIN NAME

Survivin

SYNONYMS

API4 antibody;Apoptosis inhibitor 4 antibody;Apoptosis inhibitor survivin antibody;Apoptosis inhibitor4 antibody;Baculoviral IAP repeat containing 5 antibody;Baculoviral IAP repeat containing protein 5 antibody;Baculoviral IAP repeat-containing protein 5 antibody;BIRC 5 antibody;BIRC5 antibody;BIRC5_HUMAN antibody;EPR 1 antibody;IAP4 antibody;Survivin variant 3 alpha antibody;SVV antibody;TIAP antibody

SEQUENCE SIMILARITIES

Belongs to the IAP family.

POST-TRANSLATIONAL MODIFICATION

Ubiquitinated by the Cul9-RING ubiquitin-protein ligase complex, leading to its degradation. Ubiquitination is required for centrosomal targeting.; Acetylation at Lys-129 results in its homodimerization, while deacetylation promotes the formation of monomers which heterodimerize with XPO1/CRM1 which facilitates its nuclear export. The acetylated form represses STAT3 transactivation. The dynamic equilibrium between its acetylation and deacetylation at Lys-129 determines its interaction with XPO1/CRM1, its subsequent subcellular localization, and its ability to inhibit STAT3 transactivation.; In vitro phosphorylation at Thr-117 by AURKB prevents interaction with INCENP and localization to mitotic chromosomes. Phosphorylation at Thr-48 by CK2 is critical for its mitotic and anti-apoptotic activities. Phosphorylation at Thr-34 by CDK15 is critical for its anti-apoptotic activity.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Chromosome, Midbody.

FUNCTION

Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis .Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis .Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules.Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis.The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules .May counteract a default induction of apoptosis in G2/M phase .The acetylated form represses STAT3 transactivation of target gene promoters.May play a role in neoplasia. Inhibitor of CASP3 and CASP7.Essential for the maintenance of mitochondrial integrity and function.