Protocadherin-16 is a Single-pass type I membrane protein, which consists of 3298 amino acids. It is fibroblast specific expressed and plays a role in calcium-dependent cell-cell adhesion.
Background References
1. "Multiple cadherins are expressed in human fibroblasts."Matsuyoshi N., Imamura S.Biochem. Biophys. Res. Commun. 235:355-358(1997)
2. "Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs."Nakajima D., Nakayama M., Kikuno R., Hirosawa M., Nagase T., Ohara O.Brain Res. Mol. Brain Res. 94:85-95(2001)
Tissue Specificity
Expressed in fibroblasts but not in melanocytes or keratinocytes.