Cadherin EGF LAG seven-pass G-type receptor 2 Rabbit Polyclonal Antibody
Catalog# 0905-6
Cadherin EGF LAG seven-pass G-type receptor 2 Rabbit Polyclonal Antibody
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WB
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IF-Cell
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Human
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Mouse
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unconjugated
Overview
Product Name
Cadherin EGF LAG seven-pass G-type receptor 2 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within Human Cadherin EGF LAG seven-pass G-type receptor 2 aa 21-70 / 2,923.
Species Reactivity
Human, Mouse
Validated Applications
WB, IF-Cell
Molecular Weight
Predicted band size: 317kDa
Positive Control
Recombinant protein D3 (Murine Embryonic Stem Cell Line)
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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WB
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1:500-1:1,000
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IF-Cell
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1:50-1:100
Target
Function
Cadherin EGF LAG seven-pass G-type receptor 2 belongs to the G-protein coupled receptor 2 family, highest expressed in brain and testis. The protein encoded by the gene CELSR2 is a member of the flamingo subfamily, part of the cadherin superfamily. It may have an important role in cell/cell signaling during nervous system formation.
Background References
1. "The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1."Vincent J.B., Skaug J., Scherer S.W.DNA Res. 7:233-235(2000)
2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.DNA Res. 3:321-329(1996)
Sequence Similarity
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Tissue Specificity
Highest expression in brain and testis.
Post-translational Modification
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Subcellular Location
Cell membrane
Synonyms
Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog antibody
Cadherin EGF LAG seven-pass G-type receptor 2 antibody
Cadherin family member 10 antibody
CDHF10 antibody
CELR2_HUMAN antibody
Celsr2 antibody
EGF like domain multiple 2 antibody
EGF-like protein 2 antibody
EGFL2 antibody
epidermal growth factor like 2 antibody
ExpandImages
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Western blot analysis on recombinant protein of CELSR2 using anti- CELSR2 polyclonal antibody.
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ICC image of CELSR2 antibody stained D3 (Murine Embryonic Stem Cell Line).The secondary antibody (red) was goat anti-rabbit IgG (H+L) alexa555 conjugated.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"