5T4 Recombinant Rabbit Monoclonal Antibody [SU34-05] (ET1608-37)

UNIPROT #

Q13641

PROTEIN NAME

5T4

SYNONYMS

5T4 antibody;5T4 oncofetal antigen antibody;5T4 oncofetal trophoblast glycoprotein antibody;5T4 oncotrophoblast glycoprotein antibody;5T4AG antibody;AW495680 antibody;M6P1 antibody;TPBG antibody;TPBG_HUMAN antibody;Trophoblast glycoprotein antibody

TISSUE SPECIFICITY

Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

POST-TRANSLATIONAL MODIFICATION

Highly glycosylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Trophoblast glycoprotein, also known as TPBG, 5T4, Wnt-Activated Inhibitory Factor 1 or WAIF1, is a human protein encoded by a TPBG gene. TPBG is an antagonist of Wnt/β-catenin signalling pathway. 5T4 is an antigen expressed in a number of carcinomas. 5T4 is often referred to as an oncofetal antigen due to its expression in foetal trophoblast (where it was first discovered) or trophoblast glycoprotein (TPBG). 5T4 is found in tumors including the colorectal, ovarian, and gastric. Its expression is used as a prognostic aid in these cases. It has very limited expression in normal tissue but is widespread in malignant tumours throughout their development.