ABCA1 Mouse Monoclonal Antibody [4G2]

Function

ABC1 (for ATP-binding cassette transporter 1) is a member of the family of ATP-binding cassette proteins which transport various molecules across biological membranes. ABC1 contains 2 characteristic ATP-binding domains and 12 transmembrane domains which form a channel-like structure for transport. Mutations in the ABC1 gene are implicated in Tangier disease, characterized by low serum high density lipoprotein. ABC1 is widely expressed in human tissues, with high levels of expression in liver, lung, adrenal glands, placenta and fetal tissue. ABC1 expression is induced during monocyte differentiation and upregulated in the presence of acetylated low-density lipoprotein. ABC1 may have a dual regulatory function in macrophage lipid metabolism and inflammation.

Background References

1. Okoro, E.U., et al. 2012. Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway. PLoS ONE 7: e44430.

2. Pourebrahim, R., et al. 2011. Transcription factor Zic2 inhibits Wnt/ β-catenin protein signaling. J. Biol. Chem. 286: 37732-37740.

3. Palozza, P., et al. 2011. Lycopene regulation of cholesterol synthesis and efflux in human macrophages. J. Nutr. Biochem. 22: 971-978.

4. Sanchez, V. and Dong, J.J. 2010. Alteration of lipid metabolism in cells infected with human cytomegalovirus. Virology 404: 71-77.

Subcellular Location

Membrane

UNIPROT

SwissProt: O95477 Human

Synonyms