ADD1 Mouse Monoclonal Antibody [H1-D4]

Function

Adducins are a family of cytoskeleton proteins encoded by three genes (α, β, γ). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin α is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin α and Adducin γ is ubiquitous in contrast to the restricted expression of Adducin β. Adducin β is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.

Background References

1. Kugelmann D et al. Adducin is involved in endothelial barrier stabilization. PLoS One 10:e0126213 (2015).

2. Jones SL et al. Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments. J Cell Biol 205:67-81 (2014).

Subcellular Location

Cytoplasm, cytoskeleton, cell membrane

UNIPROT

SwissProt: P35611 Human

Synonyms