AK6 Mouse Monoclonal Antibody [B1-F4]

Function

In eukaryotic systems, the process of initiating transcription from protein-coding genes requires the presence of RNA polymerase II and a broad family of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that mediate the transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH, and sequence-specific factors that regulate gene expression. TFIID, one of the basal transcription factors, facilitates the preinitiation complex assembly through direct interactions with the TATA promoter element. TAF9 (transcription initiation factor TFIID subunit 9), also known as TAF9A or TAF II p32, is a 264 amino acid nuclear protein that, is a component of the TFIID complex and is required for cell viability.

Background References

1. Feng X et al. Identification of a novel nuclear-localized adenylate kinase 6 from Arabidopsis thaliana as an essential stem growth factor. Plant Physiol Biochem 61:180-6 (2012).

2. Drakou CE et al. hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies Proteins 80(1):206-20 (2012).

Sequence Similarity

Belongs to the adenylate kinase family. AK6 subfamily.

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, chorionic villi and the central nervous system.

Subcellular Location

Nucleus.

UNIPROT

SwissProt: Q9Y3D8 Human

Synonyms