Albumin Rabbit Polyclonal Antibody

Function

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Albumin is essential for maintaining the osmotic pressure needed for proper distribution of body fluids between intravascular compartments and body tissues. It also acts as a plasma carrier by non-specifically binding several hydrophobic steroid hormones and as a transport protein for hemin and fatty acids.

Background References

1. Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., , Hayashizaki Y.;"The transcriptional landscape of the mammalian genome.";Science 309:1559-1563(2005).

2. The MGC Project Team;"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";Genome Res. 14:2121-2127(2004).

Sequence Similarity

Belongs to the ALB/AFP/VDB family.

Tissue Specificity

Plasma.

Post-translational Modification

Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.; Glycated in diabetic patients.; Phosphorylated by FAM20C in the extracellular medium.; Acetylated on Lys-223 by acetylsalicylic acid.

Subcellular Location

Secreted.

UNIPROT

SwissProt: P02768 Human

Synonyms