Alpha-Synuclein Mouse Monoclonal Antibody [2G5]
Catalog# RT1036
Alpha-Synuclein Mouse Monoclonal Antibody [2G5]
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WB
-
IP
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IF
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Human
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unconjugated
Overview
Product Name
Alpha-Synuclein Mouse Monoclonal Antibody [2G5]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
peptide
Species Reactivity
Human
Validated Applications
WB, IP, IF
Molecular Weight
19 kDa
Positive Control
293T, SH-SY5Y.
Conjugation
unconjugated
Clone Number
2G5
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at +4℃
Storage Buffer
1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1
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100-1:1,000
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IP
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1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
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IF
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1:50-500
Target
Function
The synuclein family members, including ?-synuclein (also designated NACP for non-∫-Amyloid component) and ∫-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. ?-synuclein is localized to neuronal cell bodies and synapses. ?-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation ?-synuclein has been found to be upregulated, while ∫-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of ?-synuclein has been found in patients with early onset Parkinson’s disease.
Background References
1. Jin, H., et al. 2011. α-synuclein negatively regulates protein kinase Cδδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J. Neurosci. 31: 2035-2051.
2. Ballard, C., et al. 2010. α-synuclein antibodies recognize a protein present at lower levels in the CSF of patients with dementia with Lewy bodies. Int. Psychogeriatr. 22: 321-327.
Subcellular Location
CytoplasmM embrane, Nucleus, Secreted
UNIPROT
Synonyms
Alpha synuclein antibody
Alpha-synuclein antibody
Alpha-synuclein
isoform NACP140 antibody
alphaSYN antibody
MGC105443 antibody
MGC110988 antibody
MGC127560 antibody
MGC64356 antibody
NACP antibody
ExpandImages
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Western blot analysis of α-synuclein expression in non-transfected (A) and human α-synuclein transfected (B)293T whole cell lysates.
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Western blot analysis of α-synuclein expression in SH-SY5Y whole cell lysate.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Alternative Products
Alpha-Synuclein Recombinant Rabbit Monoclonal Antibody [JB42-33]
Application: WB,IF-Cell,IF-Tissue,IHC-P,IP,FC
Reactivity: Human
Conjugate: unconjugated
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