BMP11 Rabbit Polyclonal Antibody
Catalog# R1510-15
BMP11 Rabbit Polyclonal Antibody
-
WB
-
IF-Cell
-
IHC-P
-
FC
-
Human
-
Mouse
-
Rat
Predicted species support after-sales service
-
unconjugated
Overview
Product Name
BMP11 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Recombinant protein within Human BMP11 aa 200-407.
Species Reactivity
Human, Mouse (Predicted: Rat)
Predicted species support after-sales service
Validated Applications
WB, IF-Cell, IHC-P, FC
Molecular Weight
Predicted band size: 45 kDa
Positive Control
Hela, SW480, HepG2, human colon cancer tissue, mouse brain tissue.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
-
IF-Cell
-
1:50-1:200
-
IHC-P
-
1:50-1:200
-
FC
-
1:50-1:100
-
WB
-
1:500
Target
Function
GDF-11, a member of the Transforming Growth Factor (TGF) Beta superfamily, controls anterior/posterior patterning of the axial skeleton, regulates organogenesis by controlling expression of Gdnf, contributes to the control of Hox gene expression, and induces phosphorylation of Smad2. In addition, GDF-11 mediates signaling of Nodal during left-right patterning and development of head structures and inhibits generation of new neurons by neuronal progenitors in the olfactory epithelium.
Background References
1. Poggioli T et al. Circulating Growth Differentiation Factor 11/8 Levels Decline with Age. Circ Res 118(1):29-37 (2015).
2. Egerman MA et al. GDF11 Increases with Age and Inhibits Skeletal Muscle Regeneration. Cell Metab 22:164-74 (2015).
Sequence Similarity
Belongs to the TGF-beta family.
Post-translational Modification
Synthesized as large precursor molecule that undergoes proteolytic cleavage. The mature C-terminal portion of the molecule is bound non-covalently to its N-terminal propeptide rendering it inactive. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
Subcellular Location
Secreted.
Synonyms
BMP 11 antibody
BMP-11 antibody
BMP11 antibody
Bone morphogenetic protein 11 antibody
GDF 11 antibody
GDF-11 antibody
Gdf11 antibody
GDF11_HUMAN antibody
Growth differentiation factor 11 antibody
Growth/differentiation factor 11 antibody
Images
-
Immunocytochemical staining of Hela cells using anti-BMP11 rabbit polyclonal antibody.
-
Immunocytochemical staining of SW480 cells using anti-BMP11 rabbit polyclonal antibody.
-
Immunohistochemical analysis of paraffin- embedded human colon cancer tissue using anti-BMP11 rabbit polyclonal antibody.
-
Immunohistochemical analysis of paraffin- embedded mouse brain tissue using anti-BMP11 rabbit polyclonal antibody.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"