BMP4 Mouse Monoclonal Antibody [1C-17]

Function

Tumor growth factor, or TGFβ, is the prototypic member of a family of secreted proteins that regulate cellular proliferation and differentiation. Related proteins include the activins and the bone morphogenic proteins or BMPs. Like TGFβ, the BMPs signal through a heteromeric receptor complex (TGFβ R) composed of type I (TGFβ RI) and type II (TGFβ RII) receptors. Both the type I and the type II receptors contain an intrinsic serine/threonine kinase activity. Although signaling downstream of the TGF β R is poorly understood, several proteins have been implicated. Six TGFβ/BMP effector proteins, designated Smad1-6, may function as tumor suppressors. Smad proteins have been suggested to be transcription factors, acting similarly to the Stat family which associates directly with activated receptors and then translocates to the nucleus. Evidence supporting this assertion is drawn from the observation that Smad3 physically associates with the TGFβ R complex and that Smad1 is translocated to the nucleus 30-60 minutes after the addition of BMP-4.

Background References

1. Yao C et al. MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3. Oncotarget 7:2201-19 (2016).

2. Gao Y et al. WT1 regulates the development of the posterior taste field. Development 141:2271-8 (2014).

Subcellular Location

Secreted, extracellular space, extracellular matrix.

UNIPROT

SwissProt: P12644 Human

Synonyms