CCDC51 Mouse Monoclonal Antibody [A8-F4-D1]
Catalog# M1004-7
CCDC51 Mouse Monoclonal Antibody [A8-F4-D1]
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WB
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IHC-P
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Human
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unconjugated
Overview
Product Name
CCDC51 Mouse Monoclonal Antibody [A8-F4-D1]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Recombinant protein with Human CCDC51 aa 311-411 / / 411.
Species Reactivity
Human
Validated Applications
WB, IHC-P
Molecular Weight
Predicted band size: 46 kDa
Positive Control
Recombinant protein, human liver tissue, human lung tissue, human pancreas tissue, human tonsil tissue, human thyroid tissue, human spleen tissue tissue.
Conjugation
unconjugated
Clone Number
A8-F4-D1
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
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WB
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1:500-1:1,000
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IHC-P
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1:50-1:200
Target
Function
The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC51 (coiled-coil domain containing 51) is a 411 amino acid multi-pass membrane protein that exists as two alternatively spliced isoforms. The gene encoding CCDC51 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
Background References
1. Jerber J et al. The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Hum Mol Genet 23(3):563-77 (2014).
Tissue Specificity
Isoform 1: Widely expressed. Isoform 2: Expression is barely detectable.
Subcellular Location
Membrane, nucleus.
UNIPROT
Synonyms
5730568A12Rik antibody
AI551049 antibody
CCD51_HUMAN antibody
CCDC51 antibody
Coiled coil domain containing 51 antibody
Coiled-coil domain-containing protein 51 antibody
FLJ12436 antibody
RGD1311466 antibody
Images
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Western blot analysis of CCDC51 on recombinant protein using anti-CCDC51 antibody at 1/1,000 dilution.
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Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CCDC51 antibody. Counter stained with hematoxylin
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Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-CCDC51 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-CCDC51 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CCDC51 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human thyroid tissue using anti-CCDC51 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-CCDC51 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-CCDC51 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-CCDC51 antibody. Counter stained with hematoxylin.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"