CD123 / IL3RA Recombinant Mouse Monoclonal Antibody [PSH14-51]
Catalog# HA601490
CD123 / IL3RA Recombinant Mouse Monoclonal Antibody [PSH14-51]
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FC
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Human
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unconjugated
Overview
Product Name
CD123 / IL3RA Recombinant Mouse Monoclonal Antibody [PSH14-51]
Antibody Type
Recombinant Mouse Monoclonal Antibody
Immunogen
Recombinant protein within Human CD123 aa 19-305 (Extracellular).
Species Reactivity
Human
Validated Applications
FC
Molecular Weight
Predicted band size: 43 kDa
Positive Control
Human peripheral blood cells.
Conjugation
unconjugated
Clone Number
PSH14-51
Reactivity Data
| FC | |
|---|---|
| Human |
|
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 1% BSA, 0.2% Proclean 950.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
-
FC
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1:1,000
Target
Function
Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity).
Background References
1. Pelosi E et al. CD123 a Therapeutic Target for Acute Myeloid Leukemia and Blastic Plasmocytoid Dendritic Neoplasm. Int J Mol Sci. 2023 Feb
2. Gauthier L et al. Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123. Nat Biotechnol. 2023 Sep
Subcellular Location
Cell membrane.
UNIPROT
Synonyms
CD123 antibody
CD123 antigen antibody
hIL 3Ra antibody
hIL-3Ra antibody
hIL3Ra antibody
IL 3 receptor alpha SP2 isoform antibody
IL 3R alpha antibody
IL-3 receptor subunit alpha antibody
IL-3R subunit alpha antibody
IL-3R-alpha antibody
ExpandImages
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Flow cytometric analysis of human peripheral blood cells labeling CD123 / IL3RA.
Cells were washed twice with cold PBS and resuspend. Then stained with the primary antibody (HA601490, 1/1,000) (red). After incubation of the primary antibody at +4℃ for an hour, the cells were stained with a iFluor™ 647 conjugate-Goat anti-Mouse IgG Secondary antibody (HA1127) at 1/1,000 dilution for 30 minutes at +4℃. Unlabelled sample was used as a control (cells without incubation with primary antibody; black).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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