CD14 Rabbit Polyclonal Antibody

Function

CD14 is a glycophosphatidylinositol-anchored protein expressed on the surfaces of monocytes and plymorphonuclear leukocytes. It cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). CD14 acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response and up-regulates cell surface molecules, including adhesion molecules.

Background References

1. "Crystal structure of CD14 and its implications for lipopolysaccharide signaling."Kim J.I., Lee C.J., Jin M.S., Lee C.H., Paik S.G., Lee H., Lee J.O.J. Biol. Chem. 280:11347-11351(2005)

2. "The phagosomal proteome in interferon-gamma-activated macrophages."Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.Immunity 30:143-154(2009)

Tissue Specificity

Detected on macrophages (at protein level). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.

Post-translational Modification

N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

Subcellular Location

Cell membrane, Golgi apparatus , Secreted.

UNIPROT

SwissProt: P08571 Human

SwissProt: P10810 Mouse

Synonyms