CD151 Mouse Monoclonal Antibody [3G1]

Function

CD151 is involved in a wide variety of cell biological processes, includingcell adhesion and the transport of integrins via vesicles. The human CD151gene maps to chromosome 11p15.5 and encodes a 253 amino acid protein,which belongs to the tetraspan (4TM) superfamily. CD151 can associate with several Integrin chains including β1, β3, β4, α2, α3, α5 and α6 integrins. CD151 may provide a framework for the spatial organization of both type I and type II hemidesmosomes, which are specialized junctional complexes that function as cell-attachment sites for binding to basement membranes. CD151 RNA transcript (1.6 kb) can be detected in MO7e cells, bone marrow stromal cells, C11 endothelial cells, HUVEC and several myeloid leukemia cell lines, however, no transcript is detected in brain and the lymphoblastoid cell lines MOLT-4 and BALM-1. Leu149 -Glu213 of CD151 is the interface through which Integrins α3/β1 can bind. CD151 can enhance cell motility, invasion and metastasis of cancer cells in a focal adhesion kinase dependent manner.

Background References

1. Sincock, P.M., et al. 1999. PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. J. Cell Sci. 112: 833-844.

2. Sterk, L.M., et al. 2000. The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin α6β4 and may regulate the spatial organization of hemidesmosomes. J. Cell Biol. 149: 969-982.

Subcellular Location

Cytoplasm, membrane

UNIPROT

SwissProt: P48509 Human

Synonyms