APC Conjugated CD25 / IL-2 Receptor alpha Recombinant Mouse Monoclonal Antibody [PSH14-46]
Catalog# HA601530F
APC Conjugated CD25 / IL-2 Receptor alpha Recombinant Mouse Monoclonal Antibody [PSH14-46]
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FC
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Human
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APC
Overview
Product Name
APC Conjugated CD25 / IL-2 Receptor alpha Recombinant Mouse Monoclonal Antibody [PSH14-46]
Antibody Type
Recombinant Mouse Monoclonal Antibody
Species Reactivity
Human
Validated Applications
FC
Molecular Weight
Predicted band size: 31 kDa
Positive Control
Human peripheral blood cells.
Conjugation
APC
Clone Number
PSH14-46
Reactivity Data
| FC | |
|---|---|
| Human |
|
Product Features
Form
Liquid
Concentration
Storage Instructions
Store at 2℃ to 8℃. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 1% BSA, 0.2% Proclean 950.
Isotype
IgG1
Purification Method
Protein A affinity purified.
Application Dilution
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FC
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5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Target
Function
The interleukin-2 receptor alpha chain (also called Tac antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with interleukin-2, a pleiotropic cytokine which plays an important role in immune homeostasis.
Background References
1. Pan Z et al. IL2RA(+)VSIG4(+) tumor-associated macrophage is a key subpopulation of the immunosuppressive microenvironment in anaplastic thyroid cancer. Biochim Biophys Acta Mol Basis Dis. 2023 Jan
2. Nguyen CH et al. IL2RA Promotes Aggressiveness and Stem Cell-Related Properties of Acute Myeloid Leukemia. Cancer Res. 2020 Oct
Subcellular Location
Membrane.
UNIPROT
Synonyms
Interleukin 2 receptor alpha chain antibody
CD25 antibody
CD25 antigen antibody
IDDM10 antibody
IL 2 receptor alpha subunit antibody
IL-2 receptor subunit alpha antibody
IL-2-RA antibody
IL-2R subunit alpha antibody
IL2 RA antibody
IL2 Receptor alpha antibody
ExpandImages
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Flow cytometric analysis of human peripheral blood cells labelling CD25 / IL-2 Receptor alpha (HA601530F, APC) and CD4 (HA600119F, FITC).
Cells were washed twice with cold PBS and resuspend. Then incubated for 1 hour at +4℃ with CD25 / IL-2 Receptor alpha (HA601530F, APC, 1/500) compared with Mouse IgG Isotype Control (APC, 1/1,000).
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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