CD33 Mouse Monoclonal Antibody [B7-C6]

Function

CD33 is a type I transmembrane glycoprotein that is found on granulocyte and macrophage precursors in the bone marrow, but is absent from pluripotent stem cells. CD33 is also expressed on monocytes in peripheral blood. It is used as a marker to distinguish myelogenous leukemia cells from lymphoid or erythroid leukemias. CD33 may function as a sialic acid-dependent cell adhesion molecule.

Background References

1. Siddiqui SS et al. The Alzheimer\'s Disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool. J Biol Chem pii: jbc.M117.799346 (2017).

2. Lamba JK et al. CD33 Splicing Polymorphism Determines Gemtuzumab Ozogamicin Response in De Novo Acute Myeloid Leukemia: Report From Randomized Phase III Children\'s Oncology Group Trial AAML0531. J Clin Oncol 35(23):2674-2682 (2017).

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: P20138 Human

Synonyms